We found that there was a small offset (~300 mV) at TP6 and TP8, in PD2 circuit (CH2 of the board). I replaced U3 AD822ARZ but did not see any affect. I disconnected the adaptor board in the back and saw that the offset went away. This might mean that the cable had some flaky short to a power supply pin. However, when I just reinserted the adaptor board back again, there was no offset. We could not find any issue with the board after that to fix, so we left it as it is. If this board gives offset issues in the future, most probably the ribbon cable would be the suspect.

Now all ADC channels are showing no offset or overflows in C1SU2 chassis.